  
Novel transcervical sterilization procedure successful in humans
Last Updated: 2001-05-01 17:19:04 EDT (Reuters Health)
By Steven Reinberg
CHICAGO (Reuters Health) - The Adiana procedure, a new transcervical sterilization technique, resulted in occlusion of the fallopian tube in a pilot clinical study.
The procedure involves applying radio-frequency energy to the fallopian tube, to ablate its epithelial lining, and depositing a porous plastic matrix in the tube, Dr. Dennis R. Stewart from Adiana, Inc., Redwood City, California, told an audience today at the 50th annual meeting of the American College of Obstetricians and Gynecologists.
Ablating the epithelial lining promotes cellular ingrowth into the matrix, thus permanently occluding the fallopian tubes, Dr. Stewart told Reuters Health. "The advantage of the procedure is that it can be done on an outpatient basis, because it can be done under sedation and takes only about 10 minutes to perform," he added.
"It takes about 12 weeks for the ingrowth into the matrix to completely occlude the fallopian tubes, during which time women would have to use alternate contraception," Dr. Stewart explained.
Dr. Stewart and colleagues tested the procedure on four women 12 weeks before they underwent elective hysterectomy. All of the women reported zero pain, the researchers found.
All seven tubes treated were completely blocked as indicated by hysterosalpingography. As additional evaluation, dye was applied under pressure to the explanted tube. During this procedure, six of the tubes were resistant to dye passage, whereas the other tube let dye pass after 1 minute of application, indicating only partial occlusion of the tube.
"All seven tubes exhibited host cellular infiltrate into the pores of the matrix. Immunohistologic stains indicated that a variety of host cells made up the occlusive ingrowth," the research team reported in a meeting abstract.
"This is only preliminary data, and we hope to be doing FDA-approved clinical trials in the US next year," Dr. Stewart told Reuters Health.
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