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Cataract extraction a marker for increased risk of CHD in women
Last Updated: 2001-05-02 18:11:15 EDT (Reuters Health)
WESTPORT, CT (Reuters Health) - Among women, cataract extraction is significantly associated with an increased risk of coronary heart disease, as well as with overall mortality, according to an analysis of data from the Nurses' Health Study.
It is probable that cataract formation, rather than having a cause-effect relationship with CHD, "reflects more generalized tissue damage associated with oxidative stress, which has been characterized as part of the aging process," Dr. Frank B. Hu and colleagues write in the American Journal of Epidemiology for May 1.
Dr. Hu, of Harvard School of Public Health in Boston, and his group followed 60,657 women who were 45 to 63 years of age in 1984. None had a history of coronary disease, stroke or cancer at baseline. More than 2000 women reported cataract extractions by 1992. Ten years of follow-up showed 887 incident cases of coronary heart disease and 2322 deaths.
The age-adjusted relative risk for coronary heart disease associated with cataract extraction was 2.57, and for fatal coronary heart disease it was 3.48. For overall mortality, the relative risk was 1.70. The increases in risk remained significant after adjustment for smoking, diabetes, and other covariates. The association between cataract extraction and CHD was stronger among women with a history of diabetes.
Am J Epidemiol 2001;153:875-881.
-Westport Newsroom 203 319 2700
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